Applications of CRISPR/Cas9 in Reproductive Biology

作者：Khan, Faheem Ahmed; Pandupuspitasari, Nuruliarizki Shinta; Huang ChunJie; Ahmad, Hafiz Ishfaq; Kai Wang; Ahmad, Muhammad Jamil; Zhang, ShuJun^*

来源：CURRENT ISSUES IN MOLECULAR BIOLOGY, HORIZON SCIENTIFIC PRESS, UNIT 7570, PO BOX 7169, WAREHAM RD, POOLE BH15 9EL, ENGLAND, 94-102, 2018.

DOI：10.21775/cimb.026.093

• SPERMATOGONIAL STEM-CELLS
• GENE DRIVE SYSTEM
• MALARIA MOSQUITO
• GERM-LINE
• GENOME
• MOUSE
• EMBRYOS
• VECTOR
• DISEASES
• FERTILIZATION

Genome editing is unravelling its benefits in wide areas of scientific development and understanding. The advances of genome editing from ZFNs and TALLENs to CRISPRs defines its wide applicability. Reproduction is the fundamental process by which all organisms maintain their generations. CRISPR/Cas9, a new versatile genome editing tool has been recently tamed to correct several disease causing genetic mutations, spreading its arms to improve reproductive health. It not only edits harmful genetic mutations but is also applied to control the spread of parasitic diseases such as malaria by introducing selfish genetic elements, propagated through generations and population via reproduction. These applications led us to review the recent developments of CRISPRs use in reproductive biology.

• 出版日期2018
• 单位华中农业大学