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摘要
The aim of the present research is to find the influence of honey in the metabolism of liquiritin by human intestinal flora to validate the folkloric use of honey-treated licorice (Glycyrrhiza uralensis). The metabolites of liquiritin were analyzed by HPLC-MS/MS and FT-ICR-MS/MS. The immunological effects were investigated by using an in vitro splenocyte proliferation assay. In the presence of honey, liquiritin was metabolized slowly into the main metabolite (liquiritigenin), and the other metabolite (davidigenin) was only found in low abundance. But, in the absence of honey, liquiritin was rapidly transformed into liquiritigenin, and liquiritigenin was further metabolized into davidigenin, making davidigenin the main metabolite. The splenocyte proliferation assay revealed that liquiritigenin shows remarkable immuno-enhancing effects, whereas liquiritin and davidigenin exhibit little or adverse effect on the proliferation of ConA-induced murine splenocytes. The presence of honey can alter the metabolism of liquiritin and, thus, influence the pharmacological effects of the licorice, rendering the honey-treated licorice as a medicine to invigorate the spleen.
- 出版日期2012
- 单位吉林大学; 中国科学院长春应用化学研究所
