Dual Effects of Respiratory Syncytial Virus Infections on Airway Inflammation by Regulation of Th17/Treg Responses in Ovalbumin-Challenged Mice

作者：Wang Jia; Kong Lingwen; Luo Qingli; Li Bei; Wu Jinfeng; Liu Baojun; Wu Xiao; Dong Jingcheng^*

来源：Inflammation, 2014, 37(6): 1984-2005.

DOI：10.1007/s10753-014-9931-0

• asthma exacerbation
• respiratory syncytial virus
• allergic airway inflammation
• regulatory T lymphocyte
• Th17 cell

We investigated the effects of respiratory syncytial virus (RSV) infections on ovalbumin (OVA)-challenged mice via regulation of Th17/Treg cell responses. BALB/c mice were challenged with OVA, followed by RSV infections twice. In OVA-challenged mice, the secretion of Th2/Th17-type cytokines, airway hyperresponsiveness and inflammation were significantly inhibited by initial RSV infection. Moreover, the in vivo findings demonstrated that initial RSV infection reversed the imbalance of Th17/Treg responses. In contrast, RSV re-infection strengthened Th2/Th17-type cytokine secretion, airway hyperresponsiveness, and inflammation, especially for lymphocyte infiltration in OVA-challenged mice. Meanwhile, RSV re-infection enhanced the imbalanced Th17/Treg responses. Upon all results reveal that RSV-induced respiratory infections may lead to dual effects pertaining to allergic airway inflammation by regulation of Th17/Treg responses.

• 出版日期2014-12
• 单位复旦大学