A novel reaction cascade leading to a spontaneous intramolecular dipolar cycloaddition through simultaneous generation of 1,3-dipole and dipolarophile

作者：Kalyanam Nagabushanam^*; Rapole Keshav R; Rajendran Ramanujam; Majeed Muhammed

来源：Tetrahedron Letters, 2013, 54(38): 5155-5158.

DOI：10.1016/j.tetlet.2013.07.009

• Azomethine ylid
• 1,3-Dipolar addition
• Cycloaddition
• Dipolarophile
• Stereoselective
• Bis-Schiff bases of ornithine

Ornithine methyl ester reacts with aromatic aldehydes to generate bis-Schiff bases, which depending on the structure of the aromatic aldehyde, further undergo an intramolecular cycloaddition through the transient formation of a reactive 1,3-dipole.

• 出版日期2013-9-18