科研之友
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摘要
In the title compound, C(13)H(12)ClN(5), which is a derivative of the antitumor agent pazopanib {systematic name: 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]-amino]-2-methylbenzolsulfonamide}, the indazole and pyrimidine fragments form a dihedral angle of 62.63 (5)degrees. In the crystal, pairs of molecules related by twofold rotational symmetry are linked into dimers through pi-pi interactions between the indazole ring systems [centroid-centroid distance = 3.720 (2) angstrom]. Weak intermolecular C-H center dot center dot center dot N hydrogen bonds further assemble these dimers into columns propagated in [001].
- 出版日期2010-11
- 单位天津药物研究院有限公司; 天津工业大学
