A Versatile Sugar Transferase Makes the Cut

作者：Hanover John A^*

来源：Cell, 2011, 144(3): 321-323.

DOI：10.1016/j.cell.2011.01.025

The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.

• 出版日期2011-2-4