Acrylamide applied during pregnancy causes the neurotoxic effect by lowering BDNF levels in the fetal brain

作者：Erdemli Mehmet Erman; Aladag M Arif^*; Altinoz Eyup; Demirtas Sezin; Turkoz Yusuf; Yigitcan Birgul; Bag Harika Gozukara

来源：Neurotoxicology and Teratology, 2018, 67: 37-43.

DOI：10.1016/j.ntt.2018.03.005

• Acrylamide
• Oxidative stress
• N-acetylcysteine
• Fetal brain development
• Brain-derived neurotrophic factor

Objectives: The aim of this study is to elucidate the possible mechanism of neurotoxic effect of acrylamide (AA) applied during pregnancy on fetal brain development and to show the effect of N-acetylcysteine (NAC) on AA toxicity.
Materials and methods: Four groups were formed with 9 pregnant rats each as control (C), acrylamide (AA), N-acetylcysteine (NAC), acrylamide plus N-acetylcysteine (AA plus NAC) groups. Caesarian section was implemented on the 20th day of pregnancy. Malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT) and Brain-derived neurotrophic factor (BDNF) levels were analyzed and histopathologic examinations were performed in brain tissues of the fetuses.
Results: Our data indicated that AA caused necrotic death and hemorrhagic damages in fetal brain tissue with decreasing BNDF levels and increasing oxidative stress. N-acetylcysteine prevented the toxic effects of its on fetal brain (p < 0.05).
Conclusion: Our study indicated that acrylamide has toxic effects in the fetal brain and N-acetylcysteine prevents its toxic effect.

• 出版日期2018-6