Unusual 22S-Spirostane Steroids from Dracaena cambodiana

作者：Chan Van Minh; Nguyen Tien Dat; Nguyen Hai Dang; Nguyen Hoai Nam; Ninh Khac Ban; Nguyen Van Tuyen; Le Mai Huong; Tran Thu Huong; Phan Van Kiem^*

来源：Natural Product Communications, 2009, 4(9): 1197-1200.

• Dracaena cambodiana
• Dracaenaceae
• spirostane steroid
• antimicrobial activity

From the methanol extract of Dracaena cambodiana roots two Unusual 22S-spirostane steroids (1 beta,3 beta,114 alpha,20R,22S,25R)-spirost-5-ene-1,3,14-triol (1) and (1 beta,3 beta,14 alpha,15 alpha,20R,22S,25R)-spirost-5-ene-tetrol (2) have been isolated, together with a known 22R-spirostane compound, namogenin B (3). Their structures were elucidated by spectroscopic and spectrometric methods, including HRMS and extensive ID and 2D NMR spectroscopy. Compound I showed significant antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Fusarium oxyporum, with MIC values of 45.0, 25.0 and 50.0 mu g/mL, respectively.

• 出版日期2009-9