Stem cell function and maintenance - ends that matter: Role of telomeres and telomerase

作者：Saeed Hamid^*; Iqtedar Mehwish

来源：Journal of Biosciences, 2013, 38(3): 641-649.

DOI：10.1007/s12038-013-9346-3

• Aging
• stem cells
• telomerase
• telomeres

Stem cell research holds a promise to treat and prevent age-related degenerative changes in humans. Literature is replete with studies showing that stem cell function declines with aging, especially in highly proliferative tissues/organs. Among others, telomerase and telomere damage is one of the intrinsic physical instigators that drive age-related degenerative changes. In this review we provide brief overview of telomerase-deficient aging affects in diverse stem cells populations. Furthermore, potential disease phenotypes associated with telomerase dysregulation in a specific stem cell population is also discussed in this review. Additionally, the role of telomerase in stem cell driven cancer is also briefly touched upon.

• 出版日期2013-9