Application of nuclear magnetic resonance spectroscopy for identification of ciprofloxacin crystalluria

作者：Morell Garcia Daniel^*; Barcelo Bernardino; Rodriguez Adrian; Lineiro Victor; Robles Rosa; Vidal Puigserver Joan; Costa Bauza Antonia; Grases Felix

来源：Clinica Chimica Acta, 2015, 438: 43-45.

DOI：10.1016/j.cca.2014.08.003

• Ciprofloxacin
• Urinalysis
• Urolithiasis
• NMR spectroscopy

This is a report describing a previously healthy young patient, who experienced crystalluria and non-cholestatic acute liver injury after a single intravenous dose of 400 mg. The nuclear magnetic resonance spectra confirmed that the urinary sediment in our patient was formed by pure ciprofloxacin.
The nuclear magnetic resonance spectra (H-1 NMR) of the urine sediment are a good test to confirm the composition of the crystals observed by electron microscopy and infrared spectrum. The findings indicate the importance of adequate hydration, urinalysis, measurement of pH and liver enzyme levels, prior to treatment with ciprofloxacin. Our findings also indicate that ciprofloxacin should not be administered to patients with renal tubular acidosis, due to their high urinary pH.

• 出版日期2015-1-1