Nanoparticle assisted laser desorption/ionization mass spectrometry for small molecule analytes

作者：Abdelhamid Hani Nasser

来源：Microchimica Acta, 2018, 185(3): UNSP 200.

DOI：10.1007/s00604-018-2687-8

• Nanoparticles
• Metallic nanoparticles
• Metal oxides nanoparticles
• Carbon nanomaterials
• Quantum dots
• Silicon based nanomaterials
• Matrix assisted laser desorption ionization mass spectrometry
• Surface assisted laser desorption ionization mass spectrometry
• Surface enhanced laser desorption ionization mass spectrometry
• Lowmass range

Nanoparticle assisted laser desorption/ionization mass spectrometry (NPs-ALDI-MS) shows remarkable characteristics and has a promising future in terms of real sample analysis. The incorporation of NPs can advance several methods including surface assisted LDI-MS, and surface enhanced LDI-MS. These methods have advanced the detection of many thermally labile and nonvolatile biomolecules. Nanoparticles circumvent the drawbacks of conventional organic matrices for the analysis of small molecules. In most cases, NPs offer a clear background without interfering peaks, absence of fragmentation of thermally labile molecules, and allow the ionization of species with weak noncovalent interactions. Furthermore, an enhancement in sensitivity and selectivity can be achieved. NPs enable straightforward analysis of target species in a complex sample. This review (with 239 refs.) covers the progress made in laser-based mass spectrometry in combination with the use of metallic NPs (such as AuNPs, AgNPs, PtNPs, and PdNPs), NPs consisting of oxides and chalcogenides, silicon-based NPs, carbon-based nanomaterials, quantum dots, and metal-organic frameworks.

• 出版日期2018-3