Hyaluronic acid hydrogel particles with tunable charges as potential drug delivery devices

作者：Ekici Sema; Ilgin Pinar; Butun Sultan; Sahiner Nurettin^*

来源：Carbohydrate Polymers, 2011, 84(4): 1306-1313.

DOI：10.1016/j.carbpol.2011.01.028

• Hyaluronic acid hydrogel particles
• Natural and synthetic composites
• Polyelectrolytes
• Drug release
• Biocompatible

We report the synthesis of hyaluronic acid (HA) particles with positive and negative charges on their surfaces. HA-based particles were prepared using an aqueous solution of linear HA in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT)-isooctane microemulsion system. The prepared HA particles were post modified, i.e., oxidized to aldehyde (HA-O) by NaIO(4) treatment and then these HA-O particles were reacted with cysteamine (CYs) to obtain thiol groups on the surface of the HA particles. The thiolated HA particles (HA-CYs) were further exposed to radical polymerization with an anionic monomer, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), and with a cationic monomer, 3-acrylamidopropyl-trimethylammonium chloride (APTMACl), to generate HA-based ionic hydrogel particles, HA-CYs-AMPS and HA-CYs-APTMACl, respectively. The prepared HA-based anionic and cationic particles illustrated strong pH dependent size variations. We demonstrated that HA-CYs-AMPS and HA-CYs-APTMACl particles can be used as drug delivery vehicles. Trimethoprim (TMP) and naproxen (NN) were used as model drugs in the drug delivery experiments.

• 出版日期2011-4-2