Hyaluronic Acid Layer-By-Layer (LbL) Nanoparticles for Synergistic Chemo-Phototherapy

作者：Zhao, Juan; Wan, Zhuoya; Zhou, Chuchu; Yang, Qin; Dong, Jianxia; Song, Xu^*; Gong, Tao

来源：Pharmaceutical Research, 2018, 35(10): 196.

DOI：10.1007/s11095-018-2480-8

• chemo-photothermal therapy
• hyaluronic acid
• indocyanine green
• near-infrared light
• PTX

Purpose The aim of this study was to design hyaluronic acid (HA) layer-by-layer (LbL) nanoparticles, which carried paclitaxel (PTX) and Indocyanine green (ICG) to both tumor cells and tumor associated cells to achieve synergistic chemo-photothermal therapeutic effect. @@@ Methods The LbL-engineered nanopartides (PDIH) were prepared by dopamine self-polymerization on PTX nanocrystal to form thin, surface-adherent polydopamine (PDA) films, which subsequently absorbed ICG and HA. The tumor cell and tumor associated cell targeting and antitumor efficacy of PDIH were investigated both in vitro an in vivo using 4 T1 marine mammary cancer cell lines and mice bearing orthotopic 4 T1 breast tumor. @@@ Results PDIH presented a long-rod shape in TEM and showed enhanced photothermal effect and cytotoxicity upon MR laser irradiation both in vitro and in vivo. PDIH also displayed high target ability to CD44 overexpressed tumor cells and tumor associated cells mediated by HA. In vivo antitumor study indicated that PDIH therapeutic strategy could achieve remarkable antitumor efficacy. @@@ Conclusion PDIH showed excellent tumor-targeting property and chemo-photothermal therapeutic efficacy.

• 出版日期2018-10
• 单位四川大学