Association between High-density-lipoprotein-cholesterol Levels and the Prevalence of Asymptomatic Intracranial Arterial Stenosis

作者：Li, Xin; Wang, Anxin; Wang, Jing; Wu, Jianwei; Wang, Dandan; Gao, Xiang; Wu, Shouling^*; Zhao, Xingquan^*

来源：Scientific Reports, 2017, 7(1): 573.

DOI：10.1038/s41598-017-00596-9

• CORONARY HEART-DISEASE
• TRANSCRANIAL DOPPLER
• ISCHEMIC-STROKE
• HDL-CHOLESTEROL
• CARDIOVASCULAR-DISEASE
• RISK-FACTORS
• ATHEROSCLEROSIS
• ACYLTRANSFERASE
• PREDICTORS
• MORTALITY

Intracranial atherosclerotic stenosis (ICAS) is a common cause of ischemic stroke, and a low level of high-density lipoprotein cholesterol (HDL-C) is also considered to be a predictor for stroke. However, the association between the HDL-C level and asymptomatic ICAS is uncertain. From 2010 to 2011, a random sample of 5,351 participants were enrolled in the Asymptomatic Polyvascular Abnormalities Community (APAC) study. The recruited participants were then separated into 5 roughly uniformsized factions with varying HDL-C levels. Multivariate logistic regression was implemented to assess the connection of the HDL-C levels and the prevalence of asymptomatic ICAS. The prevalence of asymptomatic ICAS showed no gradual decrease with the increase of HDL-C levels. After adjustment for conventional risk factors, HDL-C levels still showed no significant association with asymptomatic ICAS. The odds ratios ( OR) of the prevalence of asymptomatic ICAS between the first group and the other 4 groups were 0.98, 1.00, 0.92, and 0.87 with 95% confidence intervals (CI) being 0.76-1.27, 0.78-1.29, 0.71-1.19, and 0.66-1.13, respectively. The study showed little correlation between HDL-C levels and asymptomatic ICAS. Normal levels of HDL-C are not an independent risk factor for asymptomatic ICAS.

• 出版日期2017-4-3
• 单位首都医科大学; 青岛大学