A Catalytic Asymmetric Reaction Involving Enolizable Anhydrides

作者:Cornaggia Claudio; Manoni Francesco; Torrente Esther; Tallon Sean; Connon Stephen J*
来源:Organic Letters, 2012, 14(7): 1850-1853.
DOI:10.1021/ol300453s

摘要

In the presence of a highly efficient novel bifunctional organocatalyst at low loadings under mild conditions, enolizable homophthalic anhydrides can be added to a range of aromatic and aliphatic aldehydes to give dihydroisocoumarins, with excellent yields and diastereo- and enantiocontrol (up to 99% ee).

  • 出版日期2012-4-6