Association between plasma homocysteine levels and obstructive sleep apnoea in patients with ischaemic stroke

作者：Chen, Maogang; Wu, Bona; Ye, Xinchun; Zhou, Zhiming; Yue, Xuanye; Wang, Qizhang; Wang, Wanxiang; Jiang, Yongjun; Lian, Xuegan; Chen, Zhaoyao; Xu, Gelin; Liu, Xinfeng^*

来源：Journal of Clinical Neuroscience, 2011, 18(11): 1454-1457.

DOI：10.1016/j.jocn.2011.01.037

• Homocysteine
• Ischemic stroke
• Obstructive sleep apnoea syndrome
• Polysomnography

We aimed to investigate the association between plasma homocysteine and obstructive sleep apnoea (OSA) syndrome in patients with ischaemic stroke. A total of 102 patients with ischaemic stroke were classified into four OSA groups based on their apnoea-hypopnoea index (AHI): absent (AHI < 5/hour); mild (5-14/hour); moderate (15-30/hour): and severe (>30/hour). The mean (+/- standard deviation) homocysteine levels in the four OSA groups were: absent, 8.98 +/- 3.74 mu mol/L; mild, 11.46 +/- 3.31 mu mol/L; moderate, 14.18 +/- 4.36 mu mol/L; and severe, 18.57 +/- 4.56 mu mol/L; and these differences were statistically significant (p < 0.001). The Pearson correlation analysis revealed a positive correlation between homocysteine levels and the severity of AHI (r = 0.482, p < 0.001). Multiple linear regression analysis showed that AHI and folate were independent predictors of homocysteine levels (R(2) = 0.539, p < 0.001, beta for AHI = 0.259, beta for folate = -0.400). In conclusion, the severity of OSA is significantly associated with elevated homocysteine levels in patients with ischaemic stroke, and this association is independent of other factors that cause elevation in homocysteine.

• 出版日期2011-11
• 单位南京大学; 江苏大学; 南通大学