Novel Avian-Origin Influenza A (H7N9) Virus Attachment to the Respiratory Tract of Five Animal Models

作者:Siegers Jurre Y; Short Kirsty R; Leijten Lonneke M E; de Graaf Miranda; Spronken Monique I J; Schrauwen Eefje J A; Marshall Nicolle; Lowen Anice C; Gabriel Guelsah; Osterhaus Albert D M E; Kuiken Thijs; van Riel Debby*
来源:Journal of Virology, 2014, 88(8): 4595-4599.
DOI:10.1128/JVI.03190-13

摘要

We determined the pattern of attachment of the avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs, and guinea pigs and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This information contributes to our knowledge of the different animal models for influenza.

  • 出版日期2014-4

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