Anti-hyperglycemic action of apigenin-6-C-beta-fucopyranoside from Averrhoa carambola

作者：Cazarolli Luisa Helena; Kappel Virginia Demarchi; Pereira Danielle Fontana; Moresco Henrique Hunger; Costa Brighente Ines Maria; Pizzolatti Moacir Geraldo; Mena Barreto Silva Fatima Regina

来源：Fitoterapia, 2012, 83(7): 1176-1183.

DOI：10.1016/j.fitote.2012.07.003

• Averrhoa carambola
• Flavonoids
• Diabetes
• Antihyperglycemic
• Glucose uptake

A stimulatory effect of apigenin-6-C-beta-fucopyranoside (1) on glucose uptake was observed when rat soleus muscle was incubated with 1, 10 and 100 mu M of this flavonoid glycoside. The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (P13K), RO318220, an inhibitor of protein kinase C (PKC), PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and HNMPA(AM)(3), an insulin receptor tyrosine kinase activity inhibitor showed that apigenin-6-C-beta-fucopyranoside triggers different metabolic pathways in skeletal muscle. The oral administration of crude extract, fractions and isolated flavonoids (apigenin-6-C-beta-fucopyranoside (1) and apigenin-6-C-(2 ''-O-alpha-rhamnopyranosyl)-beta-fucopyranoside (2)) from Averrhoa carambola leaves exhibited a potential hypoglycemic activity in hyperglycemic normal rats. Additionally, both flavonoids significantly increased the muscle and liver glycogen content after an acute treatment. The results indicate that A. carambola can be regarded as a potent anti hyperglycemic agent with insulin secretagogue and insulin mimetic properties.

• 出版日期2012-10