Nitrogen-Containing Bisphosphonates and Cancer Immunotherapy

作者：Clezardin P^*; Massaia M

来源：Current Pharmaceutical Design, 2010, 16(27): 3007-3014.

DOI：10.2174/138161210793563545

• Bisphosphonate
• zoledronate
• IPP
• gamma delta T cell
• immunotherapy
• cancer

Bisphosphonates, especially nitrogen-containing bisphosphonates (N-BPs), are widely used to block bone destruction in cancer patients with bone metastasis because they are effective inhibitors of osteoclast-mediated bone resorption. In addition to their antiresorptive effects, preclinical evidence strongly suggests that N-BPs have anticancer activity. Some of the activities associated with N-BPs are observed in human gamma delta T cells that straddle the interface of innate and adaptive immunity and have potent anti-tumour activity. This review examines the molecular and cellular mechanisms through which N-BPs stimulate the expansion and cytotoxic activity of human gamma delta T cells. In addition, we discuss the emerging clinical evidence that N-BPs have a role in cancer immunotherapy.

• 出版日期2010