A Facile FeCl3/I-2-Catalyzed Aerobic Oxidative Coupling Reaction: Synthesis of Tetrasubstituted Imidazoles from Amidines and Chalcones

作者:Zhu Yuelu; Li Cheng; Zhang Jidong; She Mengyao; Sun Wei; Wan Kerou; Wang Yaqi; Yin Bin; Liu Ping; Li Jianli*
来源:Organic Letters, 2015, 17(15): 3872-3875.
DOI:10.1021/acs.orglett.5b01854

摘要

A facile and efficient route for the synthesis of tetrasubstituted imidazoles from amidines and chalcones via FeCl3/I-2-catalyzed aerobic oxidative coupling has been developed. This new strategy is featured by high regioselectivity and yields, good functional group tolerance, and mild reaction conditions.