科研之友
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摘要
Background: An essential milestone in pediatric transplantation is to find noninvasive biomarkers to monitor acute rejection (AR). In this retrospective (Case-control) study, we examined the role of Fas - 670A/G and Fas Ligand (FasL) - 843C/T gene polymorphisms in allograft nephropathy in pediatric renal transplant recipients. Methods: In 47 pediatric kidney transplant recipients and 20 healthy controls, Fas - 670A/G and FasL - 843C/T gene polymorphisms as well as serum soluble Fas Ligand level (sFasL) were measured. Results: Serum sFasL levels were significantly higher in transplant recipients children than that in controls (548.25 +/- 298.64 pg/ml vs 143.17 +/- 44.55 pg/ml, p = 0.0001). There was no significant difference between patients with AR and those without AR in regards to serum sFasL levels (567.70 +/- 279.87 pg/ml vs 507.85 +/- 342.80 pg/ml, p = 0.56). Fas - 670A/G genotypes or alleles were not significantly different between controls and transplant recipients and among transplant recipients with and without AR. (P > 0.05 for all). FasL - 843C/T genotypes were not different between transplant recipients and controls and among transplant recipients with and without AR (P > 0.05 for all). However, Frequency of C allele in transplant patients was significantly higher than that in the control group (44.68% vs 25%, P = 0.03). FasL - 843C/T alleles were significantly different between patients with and without AR (P = 0.03). The percentages of C allele were higher in children with AR (58.82% vs 36.67%). We found that serum FasL and serum creatinine were variables that were independently associated with AR. Conclusion: This study suggests that FasL gene polymorphisms in peripheral blood might be accurate in detecting cellular AR.
- 出版日期2016-7
