A cyclometalated diplatinum complex containing 1,1 '-bis(diphenylphosphino)ferrocene as spacer ligand: Antitumor study

作者：Samouei Hamidreza; Rashidi Mehdi^*; Heinemann Frank W

来源：Journal of Organometallic Chemistry, 2011, 696(23): 3764-3771.

DOI：10.1016/j.jorganchem.2011.08.038

• Organoplatinum
• Cyclometalation
• Phosphine ligand
• Antitumor agent
• NMR

Cyclometalated platinum(II) complex [Pt(C boolean AND N)Cl(dmso)], 1, in which C boolean AND N = N(1),C(2')-chelated deprotonated 2-phenylpyridine and dmso = dimethylsulfoxide, was reacted with 1 equiv of 1,1'-bis(diphenylphosphino) ferrocene, dppf, to give the cyclometalated diplatinum(II) complex [Pt-2(C boolean AND N)(2)Cl-2(mu-dppf)], 2, along with 0.5 equiv of unreacted dppf. However, the related reaction with 0.5 equiv of dppf produced complex 2 in pure form. Complex 2 in solution was fully characterized by using multinuclear NMR spectroscopy (H-1, C-13, P-31, and Pt-195) and a number of 2D NMR experiments. The structure of complex 2 in solid state was determined by X-ray crystallography showing that the bridging dppf ligand is arranged close to "antiperiplanar staggered" conformation. Cytotoxicity of the complex 2 was studied in three human cancer cell lines derived from ovarian carcinoma(CH1), lung carcinoma(A549), and colon carcinoma (SW480) by means of the MTT assay (MTT = 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide).

• 出版日期2011-11-15