科研之友
微信
新浪微博
Facebook
分享链接
摘要
Sleep loss produces well-characterized cognitive deficits, although there are large individual differences, with marked vulnerability or resilience among individuals. Such differences are stable with repeated exposures to acute total sleep deprivation (TSD) within a short-time interval (weeks). Whether such stability occurs with chronic sleep restriction (SR) and whether it endures across months to years in TSD, indicating a true trait, remains unknown. In 23 healthy adults, neurobehavioral vulnerability to TSD exposures, separated by 27-2,091 days (mean: 444 days; median: 210 days), showed trait-like stability in performance and subjective measures (82-95% across measures). Similarly, in 24 healthy adults, neurobehavioral vulnerability to SR exposures, separated by 78-3,058 days (mean: 935 days; median: 741 days), also showed stability (72-92% across measures). Cognitive performance outcomes and subjective ratings showed consistency across objective measures, and consistency across subjective measures, but not between objective and subjective domains. We demonstrate for the first time the stability of phenotypic neurobehavioral responses in the same individuals to SR and to TSD over longtime intervals. Across multiple measures, prior sleep loss responses are strong predictors of individual responses to subsequent sleep loss exposures chronically or intermittently, across months and years, thus validating the need for biomarkers and predictors.
- 出版日期2017-11-2
