Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder

作者：Muehleisen Thomas W; Mattheisen Manuel; Strohmaier Jana; Degenhardt Franziska; Priebe Lutz; Schultz C Christoph; Breuer Rene; Meier Sandra; Hoffmann Per; Rivandeneira Fernando; Hofman Albert; Uitterlinden Andre G; Moebus Susanne; Gieger Christian; Emeny Rebecca; Ladwig Karl Heinz; Wichmann H Erich; Schwarz Markus; Kammerer Ciernioch Jutta; Schloesser Ralf G M; Nenadic Igor; Sauer Heinrich; Moessner Rainald; Maier Wolfgang; Rujescu Dan; Lange Christoph

来源：Schizophrenia Research, 2012, 138(1): 69-73.

DOI：10.1016/j.schres.2012.03.007

• Association
• Genetic overlap
• Manic depression
• Psychotic disorder
• Cortex
• Hippocampus

A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28x10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.

• 出版日期2012-6
• 单位上海市精神卫生中心; 河北医科大学