Nanotechnological approaches for the delivery of macromolecules

作者：Crommelin DJA^*; Storm G; Jiskoot W; Stenekes R; Mastrobattista E; Hennink WE

来源：Journal of Controlled Release, 2003, 87(1-3): 81-88.

DOI：10.1016/S0168-3659(03)00014-2

• drug targeting
• nanotechnology
• liposomes
• polymers
• polyplexes
• lipoplexes

In this overview, novel approaches are described for the controlled release and/or for the targeted delivery of macromolecules such as proteins and DNA. The building stones of these highly complex systems are (phospho)lipids and/or (biodegradable) polymers. They should be carefully chosen and preparation protocols should be rationally designed to maximize chances for success.

• 出版日期2003-2-21