A Billion Ubiquitin Variants to Probe and Modulate the UPS

作者：Canadeo Larissa A; Huibregtse Jon M^*

来源：Molecular Cell, 2016, 62(1): 2-4.

DOI：10.1016/j.molcel.2016.03.023

Low-affinity but highly specific protein-protein interactions abound within the ubiquitin-proteasome system (UPS). Selection for ubiquitin variants (UbVs) that bind tightly to HECT ubiquitin ligases proved remarkably useful for probing enzyme mechanism and modulating E3 activities in cells.

• 出版日期2016-4-7