An M2 cytoplasmic tail mutant as a live attenuated influenza vaccine against pandemic (H1N1) 2009 influenza virus

作者：Hatta Yasuko; Hatta Masato; Bilsel Pamuk; Neumann Gabriele; Kawaoka Yoshihiro^*

来源：Vaccine, 2011, 29(12): 2308-2312.

DOI：10.1016/j.vaccine.2011.01.023

• Influenza vaccine
• Pandemic (H1N1) 2009
• Live attenuated vaccine
• M2 deletion

The 2009 influenza pandemic brought home the importance of vaccines in infection control. Previously, we demonstrated an M2 cytoplasmic tail mutant H5N1 influenza virus could serve as a live-attenuated vaccine. Here, we adapted that strategy, generating a mutant pandemic (H1N1) 2009 virus that grew well in cell culture, but replicated less well in mice than did wild-type virus. The mutant virus elicited sterile immunity in mice, completely protecting them from challenge with a pandemic (H1N1) 2009 virus. Our results indicate that M2 cytoplasmic tail mutants are suitable for live-attenuated vaccines against pandemic viruses.

• 出版日期2011-3-9
• 单位河北医科大学