Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells

作者：Kaomongkolgit Ruchada****^*

来源：Odontology, 2013, 101(2): 227-232.

DOI：10.1007/s10266-012-0081-2

• Alpha-mangostin
• HNSCC
• MMP-2/9

The purpose of this study was to investigate the effect of alpha-mangostin on matrix metalloproteinase (MMP)-2 and MMP-9 expression in head and neck squamous cell carcinoma (HNSCC). The human HNSCC cell lines were treated with alpha-mangostin and the cytotoxicity of alpha-mangostin in HNSCC was determined using the MTS assay. To determine the effect of alpha-mangostin on the expression of MMP-2 and MMP-9 in HNSCC, gelatin zymography and RT-PCR were performed. The results showed that alpha-mangostin increased in growth inhibition of HNSCC cell lines in a concentration-dependent manner. Treatment with alpha-mangostin decreased MMP-2 and MMP-9 expression in a concentration-dependent manner in all cell lines. These findings suggested that alpha-mangostin might be a potential therapeutic agent for HNSCC.

• 出版日期2013-7