Aqua mediated indium(III) chloride catalyzed synthesis of fused pyrimidines and pyrazoles

作者：Khurana Jitender M^*; Chaudhary Ankita; Nand Bhaskara; Lumb Anshika

来源：Tetrahedron Letters, 2012, 53(24): 3018-3022.

DOI：10.1016/j.tetlet.2012.04.001

• Pyrimidine and pyrazole derivatives
• Water
• Indium trichloride
• One-pot synthesis
• Multi-component reaction

The utilization of water as solvent and indium trichloride as promoter for the three-component combinatorial synthesis of a variety of bioactive pyrimidine and pyrazole derivatives (2-10) from aldehydes, 1,3-dicarbonyl compounds, and electron-rich amino heterocycles like 6-amino-1,3-dimethyl uracil and 3-methyl-1-phenyl-1H-pyrazol-5-amine catalyzed by indium trichloride under reflux has been studied. A new class of pyrimidine derivatives (2) has also been synthesized and the structure was confirmed by single crystal X-ray analysis. The reactions are environmentally benign, reaction product could be isolated easily and the catalyst could be recycled, which makes it an appealing synthetic protocol.

• 出版日期2012-6-13