BAALC and WT1 expressions from diagnosis to hematopoietic stem cell transplantation: consecutive monitoring in adult patients with core-binding-factor-positive AML

作者：Yoon Jae Ho; Kim Hee Je^*; Shin Seung Hwan; Yahng Seung Ah; Lee Sung Eun; Cho Byung Sik; Eom Ki Seong; Kim Yoo Jin; Lee Seok; Min Chang Ki; Cho Seok Goo; Kim Dong Wook; Lee Jong Wook; Min Woo Sung; Park Chong Won; Lim Ji Hyang

来源：European Journal of Haematology, 2013, 91(2): 112-121.

DOI：10.1111/ejh.12142

• acute myeloid leukemia
• core-binding factor
• hematopoietic stem cell transplantation
• BAALC
• WT1

No consecutive analysis of BAALC and WT1 expressions associated with core-binding factor AML (CBF-AML) from diagnosis to hematopoietic stem cell transplantation (HSCT) has yet been reported. We investigated BAALC and WT1 expressions using a method of real-time quantitative polymerase chain reaction (RQ-PCR) at diagnosis, after induction chemotherapy, at pre-HSCT, and at post-HSCT period in 45 consecutive patients [t(8,21) (n=28), inv(16) (n=17)], who received HSCT as a post-remission treatment. BAALC and WT1 RQ-PCR decrement ratio (DR) was also calculated at post-induction chemotherapy, at pre-HSCT, and at post-HSCT compared with the diagnostic level. Higher BAALC expression at diagnosis showed significantly inferior OS (P=0.031), EFS (P=0.011), and higher CIR (P=0.002) rates. At post-HSCT, both higher BAALC and WT1 expressions showed significantly inferior OS (P=0.005, 0.016), EFS (P=0.002, 0.006), and higher CIR (P=0.001, 0.003) rates. A subgroup of t(8;21) showing higher BAALC and WT1 expressions at post-HSCT were also associated with inferior OS (P=0.018, 0.015) and higher CIR rates (P=0.019, 0.011). While BAALCDR showed no significant results on outcomes, WT1 DR more than 2-log at post-HSCT showed significantly lower CIR rate (P=0.028). This study showed that higher post-HSCT BAALC and WT1 expressions in patients with CBF-AML may be good markers of minimal residual disease for the prediction of survival and relapse after HSCT.

• 出版日期2013-8