Association between OLR1 K167N SNP and Intima Media Thickness of the Common Carotid Artery in the General Population

作者：Predazzi Irene Marta^*; Norata Giuseppe Danilo; Vecchione Lucia; Garlaschelli Katia; Amati Francesca; Grigore Liliana; Cutuli Lucia; Pirillo Angela; Tramontana Simona; Romeo Francesco; Novelli Giuseppe; Catapano Alberico Luigi

来源：PLos One, 2012, 7(2): e31086.

DOI：10.1371/journal.pone.0031086

Background and Purpose: The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent. Methods - We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study). %26lt;br%26gt;Results: Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers. %26lt;br%26gt;Conclusions: These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.

• 出版日期2012-2-9