A novel peptide shows excellent anti-HIV-1 potency as a gp41 fusion inhibitor

作者：Liu, Wei; An, Xiaohong; Wang, Jiao; Zhang, Xiaoguang; Tan, Jianjun; Zhou, Zhixiang^*; Zeng, Yi^*

来源：Bioorganic & Medicinal Chemistry Letters, 2018, 28(5): 910-914.

DOI：10.1016/j.bmcl.2018.01.061

• HIV-1
• Peptide fusion inhibitor
• Gp41
• ELISA
• Terminal half-life

Fusion inhibitors of HIV prevent the virus from entering into the target cell via the interaction with gp41, which stops the process of spatial rearrangement of the viral envelope protein. A series of peptides have been designed and screened to obtain a highly potent novel sequence. Among them, CT105 possesses the most potent anti-viral ability at low nanomolar IC50 values against a panel of HIV-1 pseudoviruses from A, B, C and A(1)/D subtypes, whereas T20 shows much weaker potency. CT105 also shows excellent inhibitory activity at 260 pico molar IC50 against HIV-1 replication. As a fusion inhibitor, CT105 has a strong ability to interrupt gp41 core formation. The terminal half-life of CT105 possesses 1.72-fold longer than that of T20 as determined by developing an indirect competitive ELISA method. The results suggest that this artificial peptide CT105 could be a favorable architype for further optimization and modification.

• 出版日期2018-3-1
• 单位北京工业大学; 传染病预防控制国家重点实验室; 中国疾病预防控制中心病毒病预防控制所