An efficient regioselective sonochemical synthesis of novel 4-aryl-3-methy1-4,5-dihydro-1H-pyrazolo[3,4-b]pyridin-6(7H)-ones

作者：Roshan Abbas Azimi; Mamaghani Manouchehr^*; Mahmoodi Nosrat Ollah; Shirini Farhad

来源：Chinese Chemical Letters, 2012, 23(4): 399-402.

DOI：10.1016/j.cclet.2011.12.009

• Pyrazolo[3,4-b]pyridin-6(7H)-one
• Meldrum's acid
• 5-Amino-3-methylpyrazole
• One-pot
• Ultrasonic irradiation
• Three-component
• Regioselective

An efficient ultrasound-assisted preparation of a series of novel 4-aryl-3-methyl-4,5-dihydro-1H-pyrazclo[3,4-b]pyridin-6(7H)ones via the reaction of 5-amino-3-methyl-1H-pyrazole, Meldrum's acid and various arylaldehydes using one-pot three-component approach is described. This rapid method produced the products in short reaction times (3-4 min) and excellent yields (87-95%).

• 出版日期2012-4