Novel, Tunable, and Efficient Chiral Bisdihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation

作者：Tang Wenjun^*; Qu Bo; Capacci Andrew G; Rodriguez Sonia; Wei Xudong; Haddad Nizar; Narayanan Bikashandarkoil; Ma Shengli; Grinberg Nelu; Yee Nathan K; Krishnamurthy Dhileep; Senanayake Chris H

来源：Organic Letters, 2010, 12(1): 176-179.

DOI：10.1021/ol9025815

A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as alpha-arylenamides, alpha-(acylamino)acrylic acid derivatives, beta-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON).

• 出版日期2010-1-1