科研之友
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摘要
In this presentation, we describe a novel method for estimating the onset time course of psychophysical odor adaptation in human observers. The method employs stimulus conditions derived from an analogous stimulus paradigm in audition. To test this procedure, we used liquid-dilution olfactometry to estimate 2-bottle discrimination thresholds for brief (600 ms) presentations of vanilla odor; 17 volunteers (14 females; ages 18-24) served as participants. The adapting odorant concentration for each participant was set relative to baseline threshold for the 600-ms target alone (i.e., the same level relative to each participant's threshold). To characterize the adaptation-onset time course, we compared thresholds for targets presented simultaneously with the adapting stimulus as a function of the relative delay between the onset of the adapting stimulus and onset of the target. As predicted from the analogous auditory studies, thresholds for the target stimulus increased in an orderly manner with increases in adaptation-to-target onset delay (i.e., as the adaptation process progressively decreased sensitivity). Initial increases in threshold were consistently observed for the briefest onset delays of 50-100 ms. An onset time constant was estimated at 319 ms by fitting a 2-component exponential to the mean group function. Adaptation magnitude was dependent on the level of adapting odorant, relative to threshold. When thresholds were measured in one participant with a different, unrelated target odorant, cineole, there was no effect of the vanilla-adapting stimulus on threshold. The results suggest that olfactory rapid adaptation is measurable psychophysically within 50-200 ms after odor onset, values consistent with physiological measures of adaptation in olfactory receptor neurons. This novel stimulus paradigm offers a powerful psychophysical tool to study both odor adaptation and stimulus interactions at the olfactory periphery.
- 出版日期2010-10
