MicroRNA-585 suppresses tumor proliferation and migration in gastric cancer by directly targeting MAPK1

作者：Hu, Lei; Wu, Huo; Wan, Xiao; Liu, Liu; He, Yiren; Zhu, Liang; Liu, Shaojun; Yao, Hanhui^*; Zhu, Zhiqiang^*

来源：Biochemical and Biophysical Research Communications, 2018, 499(1): 52-58.

DOI：10.1016/j.bbrc.2018.03.116

• miR-585
• Gastric cancer
• Proliferation
• Migration
• MAPK1

Increasing evidence reveals that microRNA contributes to the development and progression of gastric cancer (GC), but the roles of miR-585 in GC remain unclear. In this study, we confirmed that miR-585 was down-regulated in GC tissues and cell lines and that miR-585 expression was related to extent of invasion, TNM stage, lymph node invasion and poor prognosis. Our results showed that miR-585 inhibits the proliferation and migration of GC, and MAPK1 is a direct and functional target of miR-585. Our study sheds light on the role of miR-585 as a suppressor for tumor growth and metastasis and raises the intriguing possibility that miR-585 may serve as a new potential marker for monitoring and treating GC.

• 出版日期2018-4-30
• 单位安徽省立医院; 安徽医科大学; 中国科学技术大学