Association of estrogen receptor alpha gene polymorphisms with bone mineral density in Chinese women: a meta-analysis

作者：Wang, C L; Tang, X Y; Chen, W Q; Su, Y X; Zhang, C X; Chen, Y M^*

来源：Osteoporosis International, 2007, 18(3): 295-305.

DOI：10.1007/s00198-006-0239-2

• bone mineral density
• Chinese women
• estrogen receptor alpha gene
• gene polymorphism
• meta-analysis

Introduction and hypothesis A large number studies have examined the association between estrogen receptor alpha (ESR-alpha) gene polymorphisms and bone mineral density (BMD) in the Chinese population. We conducted a meta-analysis to assess their pooled effects.
Methods We searched for all published articles indexed in MEDLINE, the Chinese Biomedical Database, and the Chinese Journal Full-text Database from January 1994 to April 2006. Any cross-sectional study that tested the association between ESR-alpha PvuII or XbaI genotypes and BMD at the femoral neck or spine in Chinese women was included in the review. Data were extracted independently by two reviewers using a standardized data extraction form. Sixteen eligible studies involving 4,297 Chinese women were identified.
Results The overall frequencies of X and P alleles were 28% and 40%, respectively. The PvuII polymorphism was statistically significantly associated with BMD at the femoral neck (P = 0.038 for PP = Pp = pp) but not at the lumbar spine in all women. The BMD difference for the contrasts of PP versus Pp/pp genotypes was -0.0105 (95%CI, -0.0202 similar to -0.0008) g/cm(2) (P = 0.036). The XbaI polymorphism was not associated with BMD at the femoral neck or lumbar spine.
Conclusion The PvuII polymorphism had a very weak association with femoral neck BMD whereas XbaI polymorphism was unlikely to be a predictor of femoral neck or spine BMD in Chinese women.

• 出版日期2007-3
• 单位中山大学