科研之友
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摘要
A simple and highly facile protocol has been developed for the stereoselective synthesis of 1-deoxy-norcastanospermine from readily available D-glucose. N-Methylmorpholinium hydrogen sulphate was seen for the first time as a suitable catalyst for the facile conjugate addition of an amine to a glycosyl olefinic ester. Furthermore, the key step of this strategy is the internal reductive amination of glycosyl azetidine, obtained from glycosyl beta-amino alcohol under Mitsunobu reaction conditions.
- 出版日期2013
