NHC-Catalyzed/Titanium(IV)-Mediated Highly Diastereo- and Enantioselective Dimerization of Enals

作者：Cohen Daniel T; Cardinal David Benoit; Roberts John M; Sarjeant Amy A; Scheidt Karl A^*

来源：Organic Letters, 2011, 13(5): 1068-1071.

DOI：10.1021/ol103112v

An NHC-catalyzed, diastereo- and enantioselective dimerization of enals has been developed. The use of Ti(Oi-Pr)(4) is a key element for the reactivity and selectivity of this process. The cyclopentenes are obtained with high levels of diastereo- and enantioselectivity and their synthetic utility is demonstrated by functionalization of the product alkene.

• 出版日期2011-3-4
• 单位西北大学