Asymmetric Hydrogenation of beta-Ketoesters Catalyzed by Ru Complex with Para-alkoxy Substituted MeO-BIPHEP Type Diphosphine Ligands

作者：Peng Zonghai^*; Ma Menglin; Fu Haiyan; Chen Hua; Li Xianjun

来源：Chinese Journal of Catalysis, 2010, 31(2): 191-194.

DOI：10.3724/SP.J.1088.2010.90737

• beta-ketoester
• asymmetric hydrogenation
• biaryl phosphine ligand
• ruthenium complex

A series of optically active MeO-BIPHEP type ligands, (R)-6,6'-dimethoxy-2,2'-bis(di-p-alkoxyphenyl-phosphine)-1,1'-biphenyl, were synthesized, and the ruthenium complex with these ligands, [Ru(diphosphine)(C(6)H(6))Cl]Cl, was applied for the asymmetric hydrogenation of beta-ketoesters. Influence of temperature, pressure, substrate/catalyst molar ratio, and solvents was tested. The results showed that the 98.0% of ee value was achieved for the hydrogenation of ethyl acetoacetate in EtOH. [Ru(diphosphine)(C(6)H(6))Cl]Cl showed high catalytic activity and enantioselectivity for the asymmetric hydrogenation of various beta-ketoesters.

• 出版日期2010-2
• 单位四川大学; 西华大学