AMPA-silent synapses in brain development and pathology

作者：Hanse Eric^*; Seth Henrik; Riebe Ilse

来源：Nature Reviews Neuroscience, 2013, 14(12): 839-850.

DOI：10.1038/nrn3642

Synapses are constantly generated at a high rate in the developing, prepubescent brain. Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Most of these %26apos;AMPA-silent%26apos; synapses are eliminated during the developmental period, but some are specifically selected for AMPA unsilencing by correlated pre- and postsynaptic activity as the first step in a process that leads to stabilization of the synapse. Premature, or delayed, unsilencing of AMPA-silent synapses has been implicated in neurodevelopmental disorders, and abnormal generation of AMPA-silent synapses is associated with brain trauma, addiction and neurodegenerative disorders, further highlighting the importance of AMPA-silent synapses in brain pathology.

• 出版日期2013-12