An intramolecular antiparallel G-quadruplex formed by human telomere RNA

作者:Xiao Chao Da; Shibata Tomokazu; Yamamoto Yasuhiko; Xu Yan*
来源:Chemical communications, 2018, 54(32): 3944-3946.
DOI:10.1039/c8cc01427b

摘要

Until now, RNA G-quadruplexes were believed to only adopt a parallel G-quadruplex structure. In this study, we describe the first observation of an antiparallel RNA G-quadruplex formed by human telomere RNA. This newly described topology is of great interest as it shows that RNA G-quadruplexes can also be polymorphic and adopt structures that are different from the parallel configuration.

  • 出版日期2018-4-18