New Therapeutic Approaches for Advanced Gastrointestinal Strormal Tumors

作者：Somaiah Neeta; von Mehren Margaret^*

来源：Hematology-Oncology Clinics of North America, 2009, 23(1): 139-+.

DOI：10.1016/j.hoc.2008.12.004

• Gastrointestinal stromal tumor
• Nilotinib
• Sorafenib
• HSP-90 inhibitors
• IGF-1R
• Tyrosine kinase inhibitors

The management of advanced gastronintestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.

• 出版日期2009-2