Uptake of Aortic F-18-FDG Is Correlated with Low-Density Lipoprotein Cholesterol and Leptin in a General Population

作者：Haraguchi Ai; Hayashida Naomi; Kamasaki Toshihiko; Miyamoto Izumi; Usui Toshiya; Ando Takao; Abiru Norio; Yamasaki Hironori; Chiba Kenya; Kudo Takashi; Kawakami Atsushi; Takamura Noboru^*

来源：PLos One, 2014, 9(11): e111990.

DOI：10.1371/journal.pone.0111990

Objective: This study investigated the relationship between aortic F-18-fluoro-2-deoxy-D-glucose (F-18-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population. %26lt;br%26gt;Methods: F-18-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings. %26lt;br%26gt;Results: By multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (beta = 0.001, p = 0.03) and log-leptin (beta = 0.336, p %26lt; 0.01) in all subjects. %26lt;br%26gt;Conclusion: TBR-A was significantly correlated with LDL-C and log-leptin independent from confounding factors. Our results suggest that aortic F-18-FDG uptake is a good marker of atherosclerosis, even in a general population.

• 出版日期2014-11-6