A meta-analysis platform methodology for determining the comparative effectiveness of antihepatitis C virus regimens

作者：Broglio Kristine R^*; Daar Eric S; Quintana Melanie; Yuan Yong; Kalsekar Anupama; Spellberg Brad; Lewis Roger J; Van den Akker Dan; Detry Michelle A; Trong Le; Berry Scott M

来源：Journal of Comparative Effectiveness Research, 2015, 4(2): 101-114.

DOI：10.2217/CER.14.69

• Bayesian hierarchical model
• boceprevir
• comparative effectiveness
• hepatitis C
• meta-analysis
• sustained virologic response
• telaprevir

Aim: Many hepatitis C virus regimens are unlikely to be compared head to head. In more difficult to treat populations where there is no standard of care, trials are single arm. We describe a flexible meta-analysis platform in this setting. Methods: Our metaanalysis is literature based. We illustrate our methodology and show how inference can be extended to single-arm trials. Results: As an example, in the single arm setting, a regimen with response rates of 84, 72 and 54% in genotype 1a across treatment naive, previous partial responders and previous null responders, respectively, would have 95% probability of superiority to IFN-alpha + RBV + TPV. Conclusion: This is a rigorous approach to comparative effectiveness that accounts for varying patient populations and plans for the incorporation of emerging treatments.

• 出版日期2015
• 单位UCLA