Assessment of cartilage repair after chondrocyte transplantation with a fibrin-hyaluronan matrix - Correlation of morphological MRI, biochemical T2 mapping and clinical outcome

作者：Eshed Iris^*; Trattnig Siegfried; Sharon Michal; Arbel Ron; Nierenberg Gabriel; Konen Eli; Yayon Avner

来源：European Journal of Radiology, 2012, 81(6): 1216-1223.

DOI：10.1016/j.ejrad.2011.03.031

• MRI
• Cartilage
• MACI
• T2-mapping
• Clinical scores

Objective: To evaluate change over time of clinical scores, morphological MRI of cartilage appearance and quantitative T2 values after implantation with BioCart (TM) II, a second generation matrix-assisted implantation system. %26lt;br%26gt;Methods: Thirty-one patients were recruited 6-49 months post surgery for cartilage defect in the femoral condyle. Subjects underwent MRI (morphological and T2-mapping sequences) and completed the International Knee Documentation Committee (IKDC) questionnaire. MRI scans were scored using the MR Observation of Cartilage Repair Tissue (MOCART) system and cartilage T2-mapping values were registered. %26lt;br%26gt;Analysis included correlation of IKDC scores, MOCART and T2 evaluation with each other, with implant age and with previous surgical intervention history. %26lt;br%26gt;Results: IKDC score significantly correlated with MOCART score (r = -0.39, p = 0.031), inversely correlated with previous interventions (r = -0.39, p = 0.034) and was significantly higher in patients with longer follow-up time (p = 0.0028). %26lt;br%26gt;MOCART score was slight, but not significantly higher in patients with longer term implants (p = 0.199). %26lt;br%26gt;T2 values were significantly lower in patients with longer duration implants (p %26lt; 0.001). This trend was repeated in patients with previous interventions, although to a lesser extent. %26lt;br%26gt;Conclusions: Significant improvement with time from BioCart (TM) II implantation can be expected by IKDC scoring and MRI T2-mapping values. Patients with previous knee operations can also benefit from this procedure.

• 出版日期2012-6