An evaluation of the performance of OraQuick (R) ADVANCE Rapid HIV-1/2 Test in a high-risk population attending genitourinary medicine clinics in East London, UK

作者：Zelin J^*; Garrett N; Saunders J; Warburton F; Anderson J; Moir K; Symonds M; Estcourt C

来源：International Journal of STD & AIDS, 2008, 19(10): 665-667.

DOI：10.1258/ijsa.2008.008132

• point-of-care
• oral fluid
• HIV
• rapid
• tests

To date, no data have been published on the use of OraQuick (R) ADVANCE Rapid HIV-1/2 Test (OraQuick) in the UK. We report preliminary findings of an ongoing evaluation of OraQuick in UK genitourinary (GU) medicine clinics. A total of 820 samples from patients in high-risk groups for HIV were tested with OraQuick and results were compared with standard HIV antibody testing. HIV prevalence (enzyme immunoassay [EIA]) was 5.73%, sensitivity of OraQuick was 93.64% (95% Cl 82.46-98.66%), specificity 99.87% (99.28-100%), positive predictive value 97.78% (88.27-99.94%) and negative predictive value 99.61% (98.87-99.92%). This includes three false-negatives considered to be due to observer error and now rectified by further training. This has increased test sensitivity to 100%. Our observed test performance of OraQuick compares well with EIA and with other rapid tests. We believe that simple, non-invasive antibody detection tests such as OraQuick can increase HIV testing and diagnosis in UK GU medicine and community settings.

• 出版日期2008-10