A RAPID METHOD FOR DETERMINATION OF FOUR THIOAMPHETAMINE DESIGNER DRUGS (ALEPH-4, ALEPH-8, ALEPH-13, ALEPH-17) IN HUMAN URINE

作者：Nieddu Maria; Boatto Gianpiero^*; Pirisi Maria Antonietta; Dessi Giuseppina

来源：Journal of Liquid Chromatography & Related Technologies, 2010, 33(14): 1351-1358.

DOI：10.1080/10826076.2010.488991

• ALEPH-13
• ALEPH-17
• ALEPH-4
• ALEPH-8
• ALEPH-D3
• urine

An analytical procedure for the simultaneous determination in human urine of four thioamphetamine designer drugs (ALEPH series) is reported. The quantitative analysis was performed by capillary electrophoresis with diode array detector (CE-DAD), using 2,5-dimethoxy-4-methylthioamphetamine-D3 (ALEPH-D3) as internal standard. In order to minimize interferences with matrix components and to preconcentrate target analytes, solid phase extraction was introduced in the method as a clean-up step. The method was validated according to international guidelines. Data for accuracy and precision were within required limits. Calibration curves were generated ranging from 1 to 500gmL-1 and correlation coefficients always exceeded 0.998. The method was demonstrated to be specific, simple, and reliable for the analysis of these derivatives in urine samples.

• 出版日期2010