Detrusor overactivity increases bladder wall thickness in male patients: A urodynamic multicenter cohort study

作者：De Nunzio Cosimo^*; Presicce Fabrizio; Lombardo Riccardo; Carter Simon; Vicentini Carlo; Tubaro Andrea

来源：Neurourology and Urodynamics, 2017, 36(6): 1616-1621.

DOI：10.1002/nau.23166

• benign prostatic enlargement
• benign prostatic obstruction
• lower urinary tract symptoms

AimsTo evaluate the role of Bladder wall thickness (BWT) as a predictor of Detrusor overactivity (DO) in patients with Lower urinary tract symptoms (LUTS)/Benign prostatic enlargement without Bladder Outlet Obstruction.
MethodsFrom January 1996 to December 2000, each new patient, aged 45 years or older with LUTS, underwent standard diagnostic assessment, urodynamic studies (cystometry and pressure flow studies), and ultrasound measurements of the bladder wall thickness (BWT) in two centers. In order to exclude the possible effect of benign prostatic obstruction (BPO) on detrusor thickness, patients with a Schaefer class was 2 were excluded from the study. The area under the receiver operating characteristics curve (AUC) quantified the predictive accuracy (PA) of BWT for the diagnosis of DO.
ResultsOverall 195 patients were enrolled. DO was observed in 98/195 patients (50%). The BWT presented an AUC of 0.70; 95% CI: 0.62-0.77 for the diagnosis of DO. At the best cut-off value of 3.85mm sensitivity was 73%; specificity was 59%; positive predictive value (64%, PPV). Negative predictive value (69%, NPV).
ConclusionsOur study firstly showed, how BWT in male patients may be a consequence of DO other than BPO. Our finding, if confirmed in further studies, could limit the accuracy of BWT in patients with DO and BPO.

• 出版日期2017-8