A Randomized Controlled Trial on Safety and Efficacy of Single Intramuscular versus Staggered Oral Dose of 600 000IU Vitamin D in Treatment of Nutritional Rickets

作者：Mondal Krishanu; Seth Anju^*; Marwaha Raman K; Dhanwal Dinesh; Aneja Satinder; Singh Ritu; Sonkar Pitambar

来源：Journal of Tropical Pediatrics, 2014, 60(3): 203-210.

DOI：10.1093/tropej/fmt105

• Vitamin D
• 25(OH)D
• radiological score
• nutritional rickets

Objective: Comparison of efficacy and safety of two different regimens of vitamin D-600000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks-in treatment of nutritional rickets.
Methods: Children with nutritional rickets (age: 0.5-5 years, n = 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular injection. Serum calcium, phosphate, alkaline phosphatase, urinary calcium/creatinine ratio, serum 25 hydroxy vitamin D and radiological score were compared at 12-week follow-up.
Results: No difference was found in efficacy of the two regimens on comparing biochemical and radiological parameters. Serum 25 hydroxy vitamin D > 100 ng/ml was found in two children in the oral group and one child in the intramuscular group. No child developed hypercalcemia or hypercalciuria after starting treatment.
Conclusion: Staggered oral and one-time intramuscular administrations of 600 000IU vitamin D are equally effective and safe in treatment of nutritional rickets.

• 出版日期2014-6